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  • Writer's pictureDr. Harold Pierre

Can Wegovy, Ozempic and Mounjaro Manage PCOS Symptoms?

Updated: Apr 26

Can Wegovy, Ozempic and Mounjaro Manage PCOS Symptoms?

Polycystic ovary syndrome (PCOS) is a common hormonal disorder that affects approximately 5-10% of women of reproductive age. The three main features of PCOS are irregular or absent menstrual cycles, excess androgen levels resulting in symptoms like acne and hirsutism, and polycystic ovaries. In addition, many women with PCOS struggle with obesity, insulin resistance, and fertility issues. While there is no cure for PCOS, medications like semaglutide (Ozempic) and tirzepatide (Mounjaro) are providing new treatment options that can help manage symptoms and promote weight loss.

What is PCOS?


PCOS is a complex condition caused by hormonal imbalances involving the ovaries, adrenal glands, pituitary gland, fat cells and more. Some of the most common symptoms of PCOS include:

  • Irregular, absent, or prolonged menstrual cycles

  • Acne and oily skin

  • Excess hair growth (hirsutism) on the face, chest, back, or buttocks

  • Weight gain and increased difficulty losing weight

  • Thinning hair or hair loss on the scalp (male pattern baldness)

  • Darkening of skin, particularly along neck creases, groin, and underneath breasts (acanthosis nigricans)

  • Multiple small cysts on the ovaries

In addition to the visible symptoms, PCOS causes metabolic problems like:

  • Insulin resistance and high blood sugar

  • High cholesterol and lipid levels

  • Increased inflammation

  • Oxidative stress

The exact cause of PCOS is still unknown, but research shows it often runs in families. Lifestyle factors like diet, inactivity, and obesity can worsen PCOS symptoms. Left untreated, PCOS puts women at higher risk of developing several other conditions like type 2 diabetes, heart disease, non-alcoholic fatty liver disease, anxiety, and depression.

While there is no cure, symptoms can be managed through medications, supplements, diet, and lifestyle changes to treat PCOS symptoms. Let’s look at how semaglutide (Ozempic) and tirzepatide (Mounjaro) are emerging as helpful new treatment options.

How Semaglutide (Ozempic) Helps With PCOS

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist originally approved by the FDA to treat type 2 diabetes. However, an increasing number of doctors are now prescribing semaglutide off-label to help patients with PCOS lose weight and manage symptoms.

Marketed under the brand names Ozempic and Wegovy, semaglutide is given by weekly injection and works by:

  • Slowing stomach emptying so you feel full longer

  • Reducing appetite signaling in the brain

  • Improving insulin sensitivity

Can Wegovy, Ozempic and Mounjaro Manage PCOS Symptoms?

In women with PCOS, drugs like Ozempic and Mounjaro can:

Help With Weight Loss

Obesity exacerbates nearly all PCOS symptoms, while losing just 5-10% of body weight can lead to noticeable improvements. By curbing appetite and enhancing feelings of fullness, semaglutide promotes weight loss through calorie restriction.

In a 2020 study of overweight or obese women with PCOS, those who took semaglutide lost 6-7% more weight on average compared to the placebo group over 20 weeks.

Improve Insulin Sensitivity

Insulin resistance is incredibly common in PCOS, affecting an estimated 70% of patients. This causes high blood sugar levels, increased inflammation, weight gain, and contributes to infertility issues.

By improving insulin sensitivity, semaglutide helps get blood sugar under control. Women taking semaglutide also see reductions in “bad” LDL cholesterol and triglycerides.

Reduce Androgen Levels

Excess androgen is responsible for PCOS symptoms like hirsutism, scalp hair loss, acne, and irregular menstrual cycles. Early research indicates semaglutide may lower free testosterone and hirsutism scores.

Regulate Menstrual Cycles

Irregular, absent, or prolonged menstrual cycles affect 80-90% of women with PCOS. These issues are tied to hormone imbalances and problems with ovulation.

In the 2020 PCOS study, 75% of women taking semaglutide resumed regular menstrual cycles compared to just 25% in the placebo group. Regulating menstruation can greatly improve fertility in women with PCOS.

While more research is still needed, these findings show semaglutide’s potential to address some of the key drivers of PCOS like weight gain, hyperandrogenism, and insulin resistance.

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Can Tirzepatide (Mounjaro) Also Help With PCOS?

Tirzepatide (Mounjaro) is a new once-weekly injection that was FDA approved in May 2022 for treating type 2 diabetes. Like semaglutide, tirzepatide is a GLP-1 receptor agonist. But tirzepatide also activates glucose-dependent insulinotropic polypeptide (GIP) receptors, making it the first dual GLP-1/GIP drug.

So how might tirzepatide help women with PCOS? Here’s what the early research shows:

Promotes Weight Loss

In clinical trials of patients with type 2 diabetes, tirzepatide led to significantly more weight loss compared to other diabetes medications.

  • In one 40-week study, average weight loss with tirzepatide ranged from 16.2 to 22.5 pounds depending on dosage. That’s roughly 5-7 times more weight loss than with semaglutide.

  • Up to 50% of tirzepatide patients lost 10% or more of their body weight.

For PCOS patients struggling with obesity, tirzepatide offers major weight loss potential. Even losing 5-10% of weight can greatly improve PCOS symptoms.

Lowers Blood Sugar Levels

Like semaglutide, tirzepatide improves insulin sensitivity and is highly effective at lowering A1c (a measure of blood sugar control over 3 months). Bringing down high blood sugar is key for PCOS patients at risk of developing diabetes.

In a head-to-head 40 week trial, tirzepatide lowered A1c 1.9-2.2% more than semaglutide. Tirzepatide also reduced fasting blood glucose levels 18-31 mg/dL more than semaglutide.

Fewer GI Side Effects

GLP-1 drugs often cause temporary nausea, vomiting, diarrhea and other GI side effects that can discourage patients from continuing treatment.

But the dual mechanism of tirzepatide seems to reduce these side effects compared to semaglutide. For instance, in one study only 4-7% of tirzepatide patients stopped treatment due to GI issues vs 11% of semaglutide patients.

The milder side effect profile may lead to better compliance with tirzepatide treatment.

While more studies specifically examining tirzepatide for PCOS are still needed, researchers are excited about its potential. In theory, the enhanced weight loss and blood sugar improvements with tirzepatide could translate into even better PCOS symptom management compared to semaglutide alone.

PCOS Patient Success Stories With Semaglutide and Tirzepatide

In online PCOS communities, many women are sharing positive experiences using semaglutide (Ozempic) and tirzepatide (Mounjaro) to manage PCOS symptoms:

“For the first time in over 15 years I am getting a regular period after taking Ozempic for 3 months. I’ve lost 18 pounds and my skin is the best it's ever been.”

“I’ve been taking Mounjaro for 6 weeks now. Down almost 12 pounds and periods have regulated for the first time in years! Appetite is noticeably lower and I don't crave junk food and sweets like before.”

“Started Mounjaro 2 months ago and it’s been life changing! Period came back after 8 years. Skin is clear. Energy levels up. Down 22 pounds so far.”

“Ozempic is magic! It brought my period back after 8 months MIA. Skin cleared up. Lost 30 pounds without really trying. Wish I started it years ago instead of metformin.”

“Mounjaro is definitely stronger than Ozempic for weight loss. I’m down 35 pounds in 3.5 months, I have a light period again, and skin is glowing. No side effects.”

These real-world experiences demonstrate how semaglutide and tirzepatide are helping many women with PCOS take back control of their health.

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Should You Take Ozempic and Mounjaro for PCOS Symptoms?


Mounjaro and Ozempic show significant promise in managing PCOS, but speak with your doctor to see if they may be right for your situation.

These drugs could benefit PCOS patients who:

  • Need help losing a significant amount of weight

  • Have tried other medications like metformin without much success

  • Want to improve insulin resistance and regulate blood sugar

  • Struggle with irregular or absent periods and fertility issues

  • Want to reduce excessive hair growth, acne, and other hyperandrogenic symptoms

But Ozempic and Wegovy may not be advisable for every PCOS patient. Your doctor can help weigh the pros and cons.

Things to consider:

  • These drugs are given by injection and can cause temporary GI side effects.

  • There is limited data on long term use.

  • They are expensive without insurance, ranging from $900-1500 per month.

  • Unknown effects on a developing fetus so effective contraception is critical.

  • Limited research specifically in PCOS patients so far. More studies still needed.

Work with a doctor who specializes in PCOS to determine if trying semaglutide or tirzepatide could be beneficial for you. While not a magic bullet cure, these innovative medications are providing many women with much needed relief from PCOS symptoms and empowering them to take control of their health.

Frequently Asked Questions

Q: How can medications like Ozempic and Mounjaro help women with PCOS?

A: PCOS patients often struggle with insulin resistance. medications like Ozempic and Mounjaro can help PCOS patients by improving insulin sensitivity. these drugs help normalize insulin levels for many women with PCOS. this leads to better management of PCOS symptoms associated with insulin resistance.

Q: Are drugs like Ozempic and Mounjaro similar?

A: Yes, medications like Ozempic and Mounjaro are very alike. Both are approved by the fda to treat type 2 diabetes but are now being used off-label for PCOS. These drugs are similar glp-1 receptor agonists that improve insulin levels. Many PCOS patients have tried Ozempic and Mounjaro and found them helpful.

Q: Can drugs like Ozempic be used for PCOS treatment?

A: Definitely, Ozempic is now commonly prescribed off-label to help treat PCOS. Though not officially approved for PCOS, Ozempic has been shown to help many women with a PCOS diagnosis. It can help manage PCOS symptoms like irregular periods, excess hair growth, and infertility issues. PCOS patients using Ozempic often see improvements.

Q: Are there any other medications similar to Mounjaro and Ozempic for PCOS?

A: Yes, there are other GLP-1 agonist drugs. Like Ozempic and Mounjaro, they can help treat insulin resistance and regulate menstrual cycles in women with PCOS. Speak to your doctor about these other options.

Q: Can Mounjaro help with weight loss in women diagnosed with PCOS?

A: Yes, Mounjaro can promote weight loss for many PCOS women. By improving insulin sensitivity, Mounjaro helps PCOS patients lose excess weight.

Q: Can Ozempic help with weight loss?

A: Ozempic is great for weight loss in PCOS patients. Insulin issues lead to weight gain in PCOS. Ozempic lowers insulin levels and helps burn stored fat. In studies, most women with PCOS prescribed Ozempic lost significant weight over 6 months. wegovy is also approved for weight loss but Ozempic shows similar benefits.

Q: Can medications like Ozempic and Mounjaro help with PCOS symptoms?

A: Absolutely. Medications like Ozempic and Mounjaro provide more than just weight loss for PCOS patients. They help regulate cycles, reduce hair growth, improve fertility, and more. These drugs treat the insulin resistance that drives PCOS. Many women using Ozempic or Mounjaro see broader symptom relief beyond weight changes.

Q: What are some common PCOS symptoms that these medications can help manage?

A: Irregular periods, excessive hair growth, weight gain, infertility, acne, and hair loss are some of the top PCOS symptoms. Insulin resistance contributes to these issues. Drugs like Mounjaro and Ozempic that improve insulin sensitivity have helped many PCOS women manage these stubborn symptoms.

Q: Is there a craze or hype around Ozempic and its use for PCOS?

A: Absolutely, there is growing hype for using Ozempic off-label to treat PCOS, especially for weight management. Social media has fueled excitement about Ozempic among the PCOS population. But Ozempic does carry risks like any drug. Working with a PCOS specialist is recommended.

About the author:

Dr. Harold Pierre is a board-certified anesthesiologist and addiction medicine specialist with over 20 years of experience. He is board-certified by the American Board of Anesthesiology and the American Board of Preventive Medicine.

This website is provided for educational and informational purposes only and does not constitute providing medical advice or professional services. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician or another qualified medical professional. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.

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