TLDR: There is some good about DHEA. Research indicate that supplementing with DHEA may improve bone density, skin health, sexual function, libido particularly in women over 70. Men showed fewer benefits with DHEA supplementation. However, you have to monitor labs to include hormone and lipid levels.
DHEA: Can It Help You Age Gracefully? Here’s What You Need to Know
As we age, levels of the hormone DHEA (dehydroepiandrosterone) often decline. Produced by the adrenal glands, DHEA serves as a precursor to sex hormones like testosterone and estrogen. It is the most abundant steroid hormone in the human body. Supplementing with DHEA has garnered attention recently for its potential effects in older adults. But what does the science say? Here we’ll explore research on DHEA supplementation, looking at key areas like bone density, muscle strength, body composition, cognitive function, sexual function and more. We’ll also discuss safety considerations around appropriate dosing. Understanding the hormone’s mechanisms can empower informed decisions on whether DHEA supplementation supports healthy aging.
Research suggests DHEA levels peak around age 25, then steadily decline. By 65, levels are 10-20% of peak. Low levels correlate with higher risk of erectile dysfunction in aging men and cardiovascular events in elderly women.
The DHEAge Study: A Research Into Dehydroepiandrosterone (DHEA) Potential
The influential DHEAge Study explored whether taking DHEA supplements could help offset age-related declines in health. This robust, double-blinded placebo-controlled trial involved 280 men and women between 60 and 79 years old. For one year, half the participants took 50 mg of DHEA daily while the control group took a placebo.
Researchers comprehensively evaluated health markers at the trial's start, 6 months, and 12 months. They tracked hormone levels like DHEAS, testosterone, estradiol, and assessed bone density via DEXA scans. The study also evaluated skin health, sexual function, muscle strength, and other aspects of physical and cognitive wellbeing.
How DHEA Impacts Hormone Levels in Older Adults
After 12 months, they found that the participants' blood levels of DHEAS (a sulfate form of DHEA) increased back to levels normally seen in younger folks. Very interesting!
For the women in the study, testosterone levels increased moderately but stayed within healthy limits. Levels of estradiol, a form of the hormone estrogen, also rose slightly in both men and women, though not nearly as high as what younger women produce. Notably, the men didn't experience significant changes in their testosterone. This means DHEA could affect male and female hormones differently. Most importantly, the study found no unhealthy build-up of hormones over time. So long-term DHEA use appears to be well-tolerated.
Overall, these findings suggest that taking DHEA might help maintain a healthier hormonal balance into our later decades. This could play a role in supporting general wellness as we age, especially for women.
DHEA's Potential Benefits: Bone Health, Skin Condition, and Sexual Function
The DHEAge study brought to light potential benefits of taking DHEA, especially for women over 70. One major finding was DHEA's positive impact on bone health. Elderly women showed improvements in bone mineral density, particularly in critical areas like the hip and forearm. The study also noted a reduction in bone resorption markers, indicating DHEA may help slow natural bone loss that comes with aging. This makes DHEA a potential tool to combat osteoporosis, a common concern among older adults.
In terms of skin health, DHEA supplementation seemed to offer visible perks. Women reported increased sebum production, better hydration, and reduced pigmentation - all contributing to a more youthful complexion. These changes propose DHEA may address age-related skin issues, making it an attractive option for those aiming to maintain their skin's vitality. Restoring DHEA to more youthful ranges could have wide-ranging benefits as our bodies age.
Another key finding was the enhancement in sexual function for women over 70. Participants noted an uptick in libido and sexual satisfaction, potentially linked to DHEA's positive effects on hormone levels. Interestingly, these gains were not as strong in men, implying women may see more tangible improvements in these areas with DHEA supplementation.
DHEA's Potential Side Effects and Safety Considerations
It's wise to approach DHEA carefully. The DHEAge study closely monitored participants for adverse effects. Most tolerated the 50 mg daily DHEA dose, but some concerns arose due to some negative effects of DHEA supplement.
In men taking DHEA, small prostate-specific antigen (PSA) increases occurred, a marker assessing prostate health. Though increases were small and seen in placebo groups too, this highlights the importance of monitoring hormone supplements, particularly for men.
The study also saw a slight total cholesterol increase among men over 70 on DHEA. Given this change in cholesterol level and the potential heart health impacts, individuals considering DHEA should consult their doctor to ensure safety. Monitoring health markers with a provider can help older men and women use DHEA appropriately. While research shows its potential to help aging bodies, tailored guidance is key to balancing benefits and risks. Moving ahead thoughtfully allows older adults to support quality of life as bodies and needs change.
Who Can Benefit the Most from DHEA?
Knowing the hormone pathway that DHEA affects, older women experiencing menopausal signs may benefit from a thorough evaluation of their symptoms with a qualified health provider, including a history, physical, and especially laboratory testing to identify low DHEA levels. After the completion of this process, a customized treatment plan can be discussed to address any hormonal deficiencies and imbalances.
Should You Consider Taking DHEA Supplements?
Before trying oral DHEA, consult your physician. While the DHEAge Study showed benefits for postmenopausal women, men may react differently. What works for your friend may not be right for you.
Talk to your doctor about your specific health goals and risks. Get baseline bloodwork done to determine if you truly have low DHEA. Track progress with regular checkups. DHEA can potentially influence many bodily systems, so medical supervision is key to staying safe.
Conclusion: DHEA's Role in Aging Gracefully
The hormone DHEA and its sulfate form decline as we get older. Supplementing with DHEA may help support healthy aging in some people over 60 and especially women over 70. Small studies found DHEA improved bone density, muscle strength, skin health and sexual function in older women and men. It also enhanced sense of well-being.
However, experts urge caution with DHEA due to mixed research results. While findings are promising, larger trials are still needed. DHEA doses over 50 mg daily might raise risks for side effects.
Talk to your doctor before trying DHEA. Get blood tests to check your DHEA-S levels. Make sure to monitor your health while taking it. Start with low doses. Stay realistic - DHEA isn't a cure-all and won't stop aging. But when used prudently under medical guidance, it may help seniors preserve vitality.
The key is balancing safe supplementation with healthy lifestyle habits. Work on good nutrition, staying active and reducing stress. Together with wise DHEA use, making these positive changes empowers older adults to age gracefully.
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Baulieu, E. E., Thomas, G., Legrain, S., Lahlou, N., Roger, M., Debuire, B., Faucounau, V., Girard, L., Hervy, M. P., Latour, F., Leaud, M. C., Mokrane, A., Pitti-Ferrandi, H., Trivalle, C., de Lacharrière, O., Nouveau, S., Rakoto-Arison, B., Souberbielle, J. C., Raison, J., Le Bouc, Y., Raynaud, A., Girerd, X., & Forette, F. (2000). Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: Contribution of the DHEAge Study to a sociobiomedical issue. Proceedings of the National Academy of Sciences, 97(8), 4279-4284. https://doi.org/10.1073/pnas.97.8.4279
*Disclaimer: This blog post is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your doctor or other qualified health provider with any questions you may have regarding your health or a medical condition. DHEA is classified as a dietary supplement in the United States and is not regulated by the FDA in the same way as prescription medications. The safety, efficacy, and appropriate dosage of DHEA have not been fully established for all individuals or conditions.
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